کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1930613 | 1050520 | 2011 | 6 صفحه PDF | دانلود رایگان |
Glucagon-like peptide-1 is a hormone secreted by L cells of the small intestine and stimulates glucose-dependent insulin response. Glucagon-like peptide-1 receptor agonists such as exendin-4 are currently used in type 2 diabetes, and considered to have beneficial effects on the cardiovascular system. To further elucidate the effect of glucagon-like peptide-1 receptor agonists on cardiovascular diseases, we investigated the effects of exendin-4 on intimal thickening after endothelial injury. Under continuous infusion of exendin-4 at 24 nmol/kg/day, C57BL/6 mice were subjected to endothelial denudation injury of the femoral artery. Treatment of mice with exendin-4 reduced neointimal formation at 4 weeks after arterial injury without altering body weight or various metabolic parameters. In addition, in vitro studies of isolated murine, rat and human aortic vascular smooth muscle cells showed the expression of GLP-1 receptor. The addition of 10 nM exendin-4 to cultured smooth muscle cells significantly reduced their proliferation induced by platelet-derived growth factor. Our results suggested that exendin-4 reduced intimal thickening after vascular injury at least in part by the suppression of platelet-derived growth factor-induced smooth muscle cells proliferation.
Research highlights
► Exendin-4 reduces neointimal formation after vascular injury in a mouse model.
► Exendin-4 dose not alter metabolic parameters in non-diabetic, non-obese mouse model.
► Exendin-4 reduces PDGF-induced cell proliferation in cultured SMCs.
► Exendin-4 may reduces neointimal formation after vascular injury at least in part through its direct action on SMCs.
Journal: Biochemical and Biophysical Research Communications - Volume 405, Issue 1, 4 February 2011, Pages 79–84