The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes

► Palmitoylation may target D1 receptors through selective endocytic pathways. ► The de-palmitoylated D1 receptor internalized faster than wild-type D1 receptor. ► Inhibition of clathrin endocytosis reduced de-palmitoylated D1 receptor internalization. ► Palmitoylation was not necessary for basal D1 receptor localization in caveolae.