Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells

► High-glucose induces expression of neuronal calcium sensor KChIP3, in retinal glia. ► Upregulation of KChIP3 expression is not associated with increased apoptosis. ► KChIP3 interacts with KV4 channels in retinal Müller cells. ► KV4 channel functional expression is also regulated in high glucose-treated cells. ► KChIP3 might regulate the macroscopic K+ current inactivation in these cells.