کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1930808 1050531 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway
چکیده انگلیسی

Systemic or local delivery of human tissue kallikrein gene (hTK) has been shown to be an effective strategy to alleviate cerebral ischemia/reperfusion (I/R) injury, and tissue kallikrein (TK) administration can suppress glutamate- or acidosis-mediated neurotoxicity in vitro. In the present study, the role of TK in hypoxia/reoxygenation (H/R) induced neuronal cell death was investigated. We found that TK administration could remarkably alleviate H/R-induced neuronal injury by reduction of LDH release and promotion of neuron viability. The protective effects of TK could be counteracted by bradykinin B2 receptor (B2R) antagonist HOE140, which could suppress up-regulation of TK on the ERK signal pathway under H/R condition. These results indicate that TK plays an important role in preventing neurons from H/R damage at least partially through the TK-B2R-ERK1/2 pathway.


► TK prevents cortical neurons from hypoxia/reoxygenation-induced neurotoxicity.
► TK’s protection involves the ERK1/2 signal pathway.
► Inhibition of ERK activation compromises TK’s protection.
► TK suppresses casepase-3 activity via B2R.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 407, Issue 2, 8 April 2011, Pages 283–287
نویسندگان
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