Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

► iPS cells were induced with a fluorescence monitoring system. ► ATM-deficient tail-tip fibroblasts exhibited quite a low reprogramming efficiency. ► iPS cells obtained from ATM-deficient cells had pluripotent cell characteristics. ► ATM-deficient iPS cells had abnormal chromosomes, which were accumulated in culture.