Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity

► Poly(n-butylcyano-acrylate) (PBCA) nanoparticles may be promising drug carriers. ► Influence of PBCA nanoparticles on the integrity of the blood-brain barrier in vitro. ► PBCA nanoparticles lead to a reversible disruption of the BBB in vitro after 4 h. ► Potential application as time-dependent and specific opener of the BBB.