کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1932977 1050599 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities
چکیده انگلیسی

For long-term survival in vitro and in vivo of acute myeloid leukemia cells, their adhesion to bone marrow stromal cells is indispensable. However, it is still unknown if these events are uniquely induced by the leukemic stem cells. Here we show that TF-1 human leukemia cells, once they have formed a cobblestone area by adhering to mouse bone marrow-derived MS-5 cells, can acquire some leukemic stem cell like properties in association with a change in the CD44 isoform-expression pattern and with an increase in a set of related microRNAs. These findings strongly suggest that at least some leukemia cells can acquire leukemic stem cell like properties in an adhesion-mediated stochastic fashion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 392, Issue 3, 12 February 2010, Pages 271–276
نویسندگان
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