کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933069 1050600 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
چکیده انگلیسی

Unwanted or misfolded proteins are either refolded by chaperones or degraded by the ubiquitin–proteasome system (UPS). When UPS is impaired, misfolded proteins form aggregates, which are transported along microtubules by motor protein dynein towards the juxta-nuclear microtubule-organizing center to form aggresome, a single cellular garbage disposal complex. Because aggresome formation results from proteasome failure, aggresome components are degraded through the autophagy/lysosome pathway. Here we report that small molecule isothiocyanates (ITCs) can induce formation of aggresome-like structure (ALS) through covalent modification of cytoplasmic α- and β-tubulin. The formation of ALS is related to neither proteasome inhibition nor oxidative stress. ITC-induced ALS is a proteasome-dependent assembly for emergent removal of misfolded proteins, suggesting that the cell may have a previously unknown strategy to cope with misfolded proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 2, 16 October 2009, Pages 456–462
نویسندگان
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