کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1933561 | 1050617 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estrogen receptor alpha interacts with 17β-hydroxysteroid dehydrogenase type 10 in mitochondria
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Estrogen receptor alpha interacts with 17β-hydroxysteroid dehydrogenase type 10 in mitochondria Estrogen receptor alpha interacts with 17β-hydroxysteroid dehydrogenase type 10 in mitochondria](/preview/png/1933561.png)
چکیده انگلیسی
Estrogen receptor alpha (ERα) is present in the nucleus, the cytosol and in mitochondria. The rat ERα ligand binding domain was employed as bait in a bacterial two-hybrid screening of a human heart cDNA library to detect novel protein–protein interaction partners of ERα in the heart. 17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10), which converts potent (17β-estradiol) to less potent estrogens (estrone), co-localized with 17β-HSD10 in the mitochondria of rat cardiac myocytes. GST pull-down experiments confirmed the interaction of ERα and 17β-HSD10. These findings suggest that the ERα estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17β-HSD10 activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 384, Issue 4, 10 July 2009, Pages 450–454
Journal: Biochemical and Biophysical Research Communications - Volume 384, Issue 4, 10 July 2009, Pages 450–454
نویسندگان
Virginija Jazbutyte, Franz Kehl, Ludwig Neyses, Theo Pelzer,