کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934314 | 1050637 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adiponectin multimer distribution in patients with familial combined hyperlipidemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Adiponectin is secreted from adipocytes in different multimers, of which the high molecular weight (HMW) form is supposed to mediate favorable metabolic and anti-atherogenic effects. We determined adiponectin multimers in 29 female and 22 male patients with familial combined hyperlipidemia (FCH) and 51 age-, gender-, and BMI-matched controls in relation to cardiovascular disease (CVD). We observed a clear sexual dimorphism of total adiponectin and its multimers. Female, but not male, FCH patients had significant lower total adiponectin and both HMW and low molecular weight (LMW) adiponectin than controls. The adiponectin sensitivity index (ASI), reflected by HMW/total adiponectin, and the LMW/HMW adiponectin ratio did not differ significantly between FCH females and control females. However, FCH females with CVD exhibited significantly lower ASI (34.2 ± 10.1% vs 46.0 ± 7.1%) and higher LMW/HMW ratio (1.5 ± 0.8 vs 0.7 ± 0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 376, Issue 1, 7 November 2008, Pages 164-168
Journal: Biochemical and Biophysical Research Communications - Volume 376, Issue 1, 7 November 2008, Pages 164-168
نویسندگان
Tim B. Koenen, Lambertus J.H. van Tits, Suzanne Holewijn, Heidi L.M. Lemmers, Martin den Heijer, Anton F.H. Stalenhoef, Jacqueline de Graaf,