کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1934350 1050638 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs
چکیده انگلیسی

Aims. Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling. Methods. Twenty dogs were randomly divided into sham-operated, control, and probucol-treated groups. We identified apoptosis and histopathological changes in the atria. Oxidative stress was measured by lipid peroxidation and echocardiographic examinations were performed. Results. Atrial apoptosis indexes were dramatically decreased in the probucol-treated group compared to the control group. Relative to the control group, the percentage of myolysis was dramatically decreased in the probucol-treated group (p < 0.01). There was less lipid peroxidation in the probucol-treated group than the control group. Atrial function was dramatically elevated in the probucol-treated group. Conclusions. The results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 381, Issue 2, 3 April 2009, Pages 198–203
نویسندگان
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