کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1934393 1050639 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
α/β hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
α/β hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase
چکیده انگلیسی

Renal dopamine receptors have been shown to play a critical role in ROS-dependent hypertension. D5 dopamine receptor deficient (D5−/−) mice are hypertensive and have increased systemic oxidative stress which is manifested in the kidney and the brain. To further investigate the underlying mechanisms of hypertension in D5−/− mice, we used RNA arrays to compare mRNA levels of kidneys from wildtype and D5−/− mice. Our data show, that the mRNA level of α/β hydrolase 1 (ABHD1) is significantly upregulated in D5−/− mice. Additionally, overexpression of ABHD1 in a new established renal proximal tubule cell line reduced the amount of O2- produced by the NADPH oxidase. Therefore the upregulation of ABHD1 in D5−/− mice could be an answer to the increased oxidative stress. While oxidative stress is an important factor for the development of hypertension, ABHD1 could play a protective role in the pathogenesis of hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 1, 30 January 2009, Pages 81–85
نویسندگان
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