کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934568 | 1050644 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition](/preview/png/1934568.png)
Our recent work suggested that early infusion of nitrite might represent a novel therapeutic approach for acute ischemic stroke. In this study, we sought to examine the therapeutic time window of nitrite in an experimental stroke model, and to develop combined strategies for augmenting its protective effects. Nitrite was infused at various times after ischemia to rats subjected to transient or permanent focal ischemia. Nitrite was infused with memantine to prevent the potential toxicity. Infarct volumes, functional outcomes, microhypoxic areas, and oxidative stress were measured. Nitrite reduced the infarction volume and enhanced functional recovery when administered within 3 and 1.5 h in the transient and permanent model, respectively. Combined therapy with nitrite and memantine prolonged the time window up to 4.5 h. The potential oxidative toxicities of nitrite were significantly inhibited by memantine. The combination therapy of nitrite and memantine may be a feasible therapeutic approach for acute ischemic stroke.
Journal: Biochemical and Biophysical Research Communications - Volume 378, Issue 3, 16 January 2009, Pages 507–512