کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935010 1050656 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients
چکیده انگلیسی

The mechanisms by which neurons die in Huntington’s disease (HD) are uncertain, however, mitochondrial dysfunction and apoptosis have been implicated. Because peripheral abnormalities may reflect similar consequences of mutant huntingtin in the brain, we evaluated markers of apoptotic cell death and mitochondrial function in peripheral blood cells of 10 HD patients and 16 age- and gender-matched controls. We found increased Bax expression in B and T lymphocytes, and monocytes from HD patients, but no alterations in Bcl-2 expression levels. B lymphocytes also showed decreased mitochondrial membrane potential. However, HD peripheral blood cells showed no differences in reactive oxygen species (ROS) levels when compared to controls. Our results suggest that peripheral blood cells, in particularly B lymphocytes may reflect changes observed in HD brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 374, Issue 4, 3 October 2008, Pages 599–603
نویسندگان
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