کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935065 1050657 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription
چکیده انگلیسی

A major feedback mechanism of cholesterol in transcription of cholesterol metabolism-related genes is mediated by sterol regulatory element-binding protein (SREBP). Involvement of glycosphingolipids (GSLs) in the SREBP pathway is unknown. In this study, we examined the effects of GSL depletion on SRE-mediated gene transcription using GSL-defective cells. We found that the content of mature SREBP, the transcriptional active form, is increased in the GSL-defective cells. Transcription of SREBP target genes and cholesterol synthesis are also induced in the GSL-defective cells. These results indicate that GSL deficiency up-regulates the SREBP pathway, pointing out the regulatory role of GSL in cholesterol homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 378, Issue 2, 9 January 2009, Pages 240–243
نویسندگان
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