کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935110 1050658 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TiO2 nanoparticles promote β-amyloid fibrillation in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
TiO2 nanoparticles promote β-amyloid fibrillation in vitro
چکیده انگلیسی

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. The pathogenesis of AD is associated with β-amyloid (Aβ) fibrillation. Nanoparticles have large surface area and can access the brain. But no investigation has been made to study the relationship between nanoparticles and AD. In our study, we observed Aβ fibril formation in the presence of six kinds of nanoparticles and found that TiO2 nanoparticles can promote Aβ fibrillation by shortening nucleation process, which is the key rate-determining step of fibrillation. Hereby the interaction between Aβ and nanoparticles may contribute to AD etiology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 373, Issue 2, 22 August 2008, Pages 315–318
نویسندگان
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