کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935180 1050660 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3
چکیده انگلیسی

Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells. ASIC3−/− mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity. Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25–27 weeks) ASIC3+/+ mice. Moreover, the enhanced glucose control in aging ASIC3−/− mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues. Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 371, Issue 4, 11 July 2008, Pages 729–734
نویسندگان
, , , , ,