کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1935323 | 1050663 | 2008 | 5 صفحه PDF | دانلود رایگان |
Alpha (α)-actinin-3 is located in the skeletal muscle Z-line and forms actin–actin crosslinks. An interesting property of α-actinin-3 is its expression pattern, which is restricted to fast type II skeletal muscle fibers. However, little is known about the response of α-actinin-3 levels to changes in skeletal muscle such as fiber type transformation. This study examined α-actinin-3 levels in the soleus muscles of rats subjected to hindlimb unloading, which causes a slow-to-fast fiber transformation in the soleus muscle. After unloading, type II myosin heavy chain (MyHC) and fast myosin levels increased significantly (P < 0.0001 for type II MyHC, P < 0.005 for fast myosin). Along with these increases in fast fibers, α-actinin-3 expression levels increased significantly (P < 0.0007) and dramatically. These results indicate that α-actinin-3 levels increase concomitantly with increases in skeletal muscle fast fibers.
Journal: Biochemical and Biophysical Research Communications - Volume 372, Issue 4, 8 August 2008, Pages 584–588