کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935719 1050673 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation
چکیده انگلیسی

Voltage-dependent K+ channels (Kv) are involved in myocyte proliferation and differentiation by triggering changes in membrane potential and regulating cell volume. Since Kv7 channels may participate in these events, the purpose of this study was to investigate whether skeletal muscle Kv7.1 and Kv7.5 were involved during proliferation and myogenesis. Here we report that, while myotube formation did not regulate Kv7 channels, Kv7.5 was up-regulated during cell cycle progression. Although, Kv7.1 mRNA also increased during the G1-phase, pharmacological evidence mainly involves Kv7.5 in myoblast growth. Our results indicate that the cell cycle-dependent expression of Kv7.5 is involved in skeletal muscle cell proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 369, Issue 4, 16 May 2008, Pages 1094–1097
نویسندگان
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