کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936581 1050695 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells
چکیده انگلیسی

Kv channels represent new important targets for the control of cancer growth and a better understanding of their regulating pathways in cancer cells is necessary to develop therapeutic strategies. In this study, we have addressed the putative modulation of Kv by MAP kinases through a pharmacological approach. We have found that the commonly used JNK inhibitor SP600125 strongly inhibits Kv channels through a JNK-independent pathway, likely interacting directly with the channels at the external side of the membrane. Our results indicate that the use of this compound may produce misleading conclusions for the role of JNK in cell cycle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 366, Issue 4, 22 February 2008, Pages 944–950
نویسندگان
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