کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936827 1050703 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Production of a novel neuromelanin at the sevoflurane–water interface
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Production of a novel neuromelanin at the sevoflurane–water interface
چکیده انگلیسی

Postoperative cognitive dysfunction (POCD) occurs in the elderly following surgery that requires inhaled anesthetics. The molecular mechanism associated with this process is unknown. This study examined the possible role of serotonin, a neurotransmitter involved in cognition. We observed that sevoflurane, a common inhaled anesthetic, formed a separate phase in water similar to that of chloroform. Additionally, sevoflurane sequestered acrolein, which is a lipid peroxidation product associated with aging and is elevated in the elderly brain. The enhanced partitioning of acrolein increased the focal concentration and hence reactivity to serotonin which preferentially occurred at the sevoflurane–water interface. The resulting product exhibited unique properties similar to catecholamine-derived neuromelanin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 363, Issue 1, 9 November 2007, Pages 77–81
نویسندگان
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