کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936917 1050705 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-κB activation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-κB activation
چکیده انگلیسی

X chromosome-linked inhibitor of apoptosis protein is an endogenous inhibitor of caspases and is an important regulator of cell death. XIAP can also influence cell signaling, but downstream proteins affected are largely unknown. We show here using neuronal PC6.3 cells that XIAP increases the levels of antioxidants, particularly superoxide dismutase-2 that is localized to mitochondria. Studies using reporter constructs and NF-κB Rel-A deficient mouse embryonic fibroblasts showed that NF-κB signaling is required for the induction of Sod2 by XIAP. XIAP also reduced oxidative stress in the PC6.3 cells as shown by decreased production of reactive oxygen species. These findings disclose a novel role for XIAP in control of oxidative stress and mitochondrial antioxidants that may contribute to cell protection after various injuries.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 364, Issue 1, 7 December 2007, Pages 138–144
نویسندگان
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