کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937087 1050708 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal
چکیده انگلیسی

Cyclophilin A (CypA), a peptidyl–prolyl cis–trans isomerase (PPIase), was originally identified as the intracellular receptor for cyclosporin A (CsA). Recently, correlations of CypA with tumor pathogenesis have been studied. Here, we studied the expression of CypA and its receptor CD147 in several kinds of lung cancer cells as well as a normal lung cell and found that in H446 cell, a kind of small cell lung cancer cell, the expression are the highest. The exogeneous CypA protein can substantially stimulate H446 cell growth in dependence on its PPIase activity. We also showed that CypA protein can stimulate ERK1/2 signal in dose and time dependent manners and almost has no effect to p38 and JNK signals. Elucidation of the precise role of CypA in these pathways may lead to new targeted therapies for small cell lung cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 361, Issue 3, 28 September 2007, Pages 763–767
نویسندگان
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