کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1937423 | 1050716 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phospholemman expression is high in the newborn rabbit heart and declines with postnatal maturation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phospholemman expression is high in the newborn rabbit heart and declines with postnatal maturation Phospholemman expression is high in the newborn rabbit heart and declines with postnatal maturation](/preview/png/1937423.png)
چکیده انگلیسی
Phospholemman (PLM) is a small sarcolemmal protein that modulates the activities of Na+/K+-ATPase and the Na+/Ca2+ exchanger (NCX), thus contributing to the maintenance of intracellular Na+ and Ca2+ homeostasis. We characterized the expression and subcellular localization of PLM, NCX, and the Na+/K+-ATPase α1-subunit during perinatal development. Western blotting demonstrates that PLM (15 kDa), NCX (120 kDa), and Na+/K+-ATPase α-1 (â¼100 kDa) proteins are all more than 2-fold higher in ventricular membrane fractions from newborn rabbit hearts (1-4-day old) compared to adult hearts. Our immunocytochemistry data demonstrate that PLM, NCX, and Na+/K+-ATPase are all expressed at the sarcolemma of newborn ventricular myocytes. Taken together, our data indicate that PLM, NCX, and Na+/K+-ATPase α-1 proteins have similar developmental expression patterns in rabbit ventricular myocardium. Thus, PLM may have an important regulatory role in maintaining cardiac Na+ and Ca2+ homeostasis during perinatal maturation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 2, 6 April 2007, Pages 338-341
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 2, 6 April 2007, Pages 338-341
نویسندگان
Shekhar Srivastava, Steven E. Cala, William A. Coetzee, Michael Artman,