کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1937424 | 1050716 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (PÂ =Â 0.0130), advanced nephropathy (stage III or IV) (PÂ =Â 0.0151), or neuropathy (PÂ =Â 0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (PÂ =Â 0.0212), nephropathy stage (PÂ =Â 0.0052), and neuropathy (PÂ =Â 0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (PÂ =Â 0.0144), nephropathy stage (PÂ =Â 0.0111), and neuropathy (PÂ =Â 0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (PÂ =Â 0.0318) or serum creatinine (PÂ =Â 0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 2, 6 April 2007, Pages 342-346
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 2, 6 April 2007, Pages 342-346
نویسندگان
Haruhiko Osawa, Masaaki Ochi, Kenichi Kato, Junko Yamauchi, Wataru Nishida, Yasunori Takata, Ryoichi Kawamura, Hiroshi Onuma, Tomomi Takasuka, Ikki Shimizu, Yasuhisa Fujii, Jun Ohashi, Hideichi Makino,