کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937644 1050722 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells
چکیده انگلیسی

p120-Catenin contributes to the cadherin-mediated adhesion and aggregation of cells. μ-Calpain was activated and p120-catenin was degraded after 36 h of ischemia in differentiated SH-SY5Y cells. Calpain inhibitors Cbz-Val-Phe-H (MDL28170, 20 μM) and N-acetyl-leucyl-leucyl-norleucinal (ALLN, 20 μM) increased the levels of dephosphorylated p120-catenin, aggregation, and cell survival as detected by reduced LDH release in ischemic cells. However, a proteasome inhibitor lactacystin had no such effects. This is the first report of the calpain-mediated degradation of p120-catenin and an association between the level of dephosphorylated p120-catenin and cell aggregation in ischemic neuronal cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 353, Issue 3, 16 February 2007, Pages 547–552
نویسندگان
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