کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1938853 1050748 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia/reperfusion injury in rat liver
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia/reperfusion injury in rat liver
چکیده انگلیسی

This study examined the effects of ischemic preconditioning (IPC), allopurinol (Allo) or a combination of both on the extent of mitochondrial injury caused by hepatic ischemia/reperfusion (I/R). I/R increased the serum aminotransferase activity and the level of mitochondrial lipid peroxidation, whereas it decreased the mitochondrial glutathione level. Either IPC or Allo alone attenuated these changes with Allo + IPC having a synergistic effect. Allo increased the serum nitrite and nitrate level after brief ischemia. The significant peroxide production observed after 10 min of reperfusion after sustained ischemia was markedly attenuated by Allo + IPC. The mitochondria isolated after I/R were swollen, which was reduced by Allo + IPC. At the end of ischemia, the hepatic ATP level was lower and there was significant xanthine accumulation, which was attenuated by Allo + IPC. These results suggest that IPC and Allo act synergistically to protect cells against mitochondrial injury and preserve the hepatic energy metabolism during hepatic I/R.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 349, Issue 3, 27 October 2006, Pages 1087–1093
نویسندگان
, ,