کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1938860 | 1050748 | 2006 | 6 صفحه PDF | دانلود رایگان |
Pyrroloquinoline quinone (PQQ) is a noncovalently bound cofactor in the bacterial oxidative metabolism of alcohols. PQQ also exists in plants and animals. Due to its inherent chemical feature, namely its free-radical scavenging properties, PQQ has been drawing attention from both the nutritional and the pharmacological viewpoint. α-Synuclein, a causative factor of Parkinson’s disease (PD), has the propensity to oligomerize and form fibrils, and this tendency may play a crucial role in its toxicity. We show that PQQ prevents the amyloid fibril formation and aggregation of α-synuclein in vitro in a PQQ-concentration-dependent manner. Moreover, PQQ forms a conjugate with α-synuclein, and this PQQ-conjugated α-synuclein is also able to prevent α-synuclein amyloid fibril formation. This is the first study to demonstrate the characteristics of PQQ as an anti-amyloid fibril-forming reagent. Agents that prevent the formation of amyloid fibrils might allow a novel therapeutic approach to PD. Therefore, together with further pharmacological approaches, PQQ is a candidate for future anti-PD reagent compounds.
Journal: Biochemical and Biophysical Research Communications - Volume 349, Issue 3, 27 October 2006, Pages 1139–1144