کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1939123 1050755 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel protein, Romo1, induces ROS production in the mitochondria
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A novel protein, Romo1, induces ROS production in the mitochondria
چکیده انگلیسی

The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 347, Issue 3, 1 September 2006, Pages 649–655
نویسندگان
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