کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1939127 1050755 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation
چکیده انگلیسی

The crosstalk between the P2Y2 G-protein-coupled receptor (GPCR) with TrkA receptor tyrosine kinase (RTK) is an important mechanism that regulates neuronal differentiation. We show that Src family kinases (SFK) regulate P2Y2-TrkA molecular crosstalk. SFK inhibitors block ATPγS/P2Y2-promoted enhancement of NGF/TrkA signaling and neuronal differentiation in PC12 cells, abrogate the enhancement by ATPγS of neurite outgrowth in primary cultures of dorsal root ganglion neurons, and block co-immunoprecipitation of TrkA, P2Y2 receptors and SFK. These results identify SFK as mediating nucleotide-enhanced neurotrophin-dependent neuronal differentiation and thus, as a key convergence point for interaction between RTKs and GPCRs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 347, Issue 3, 1 September 2006, Pages 678–682
نویسندگان
, , ,