کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1939689 1050765 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson’s disease
چکیده انگلیسی

DJ-1 is an antioxidant protein whose loss of function by gene mutations has been linked to familial Parkinson’s disease (PD). The main objective of the present study was to determine if this molecule was also involved in the pathogenesis of sporadic PD. For this purpose, quantitative immunoblot assays were performed to evaluate DJ-1 in cerebrospinal fluids (CSF) collected from sporadic PD patients (n = 40) and non-PD controls (n = 38). The results showed that the CSF DJ-1 levels in PD were significantly higher than those in non-PD controls. Especially, upregulation of CSF DJ-1 in the early stage of PD (Yahr I–II) were distinct compared to those in the advanced stage of PD (Yahr III–IV) and non-PD controls (p < 0.001 by ANOVA with post hoc Bonferroni’s test), suggesting a protective role of DJ-1 against oxidative stress during the early stage. Thus, we propose that CSF DJ-1 could be a possible biomarker for early sporadic PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 345, Issue 3, 7 July 2006, Pages 967–972
نویسندگان
, , , , , , , , ,