کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1939964 | 1050771 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
p66Shc gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
p66Shc protein has been proposed to be an indispensable factor for p53-dependent, mitochondria-mediated apoptosis in mice. Here, we show that p66Shc plays a pro-apoptotic role also in cell lines of human origin such as SaOs-2 and HeLa, where p53 is either absent or inactivated, thus, suggesting that p66Shc pro-apoptotic role is independent from the presence of a functional form of p53. The active form of p66Shc is phosphorylated in Serine 36. We confirm the importance of Serine 36 phosphorylation for p66Shc pro-apoptotic role, and our results suggest that the kinase involved in this process is activated independently from p53.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 342, Issue 2, 7 April 2006, Pages 503–508
Journal: Biochemical and Biophysical Research Communications - Volume 342, Issue 2, 7 April 2006, Pages 503–508
نویسندگان
Luca Tiberi, Amir Faisal, Matteo Rossi, Lucia Di Tella, Claudio Franceschi, Stefano Salvioli,