کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944076 1053177 2015 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ion channels in the regulation of apoptosis
ترجمه فارسی عنوان
کانال های یون در تنظیم آپوپتوز
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Ion channels are essential regulators of apoptosis.
• Ion channels could be used to target apoptosis in cancer.
• The contribution of ion channels to apoptosis varies depending on cancer type.
• Ion channels targeting has good prospects for personalized cancer therapy.

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism utilized by multicellular organisms for disposal of cells that are no longer needed or potentially detrimental. Given the crucial role of apoptosis in physiology, deregulation of apoptotic machinery is associated with various diseases as well as abnormalities in development. Acquired resistance to apoptosis represents the common feature of most and perhaps all types of cancer. Therefore, repairing and reactivating apoptosis represents a promising strategy to fight cancer. Accumulated evidence identifies ion channels as essential regulators of apoptosis. However, the contribution of specific ion channels to apoptosis varies greatly depending on cell type, ion channel type and intracellular localization, pathology as well as intracellular signaling pathways involved. Here we discuss the involvement of major types of ion channels in apoptosis regulation. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

Figure optionsDownload high-quality image (217 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1848, Issue 10, Part B, October 2015, Pages 2532–2546
نویسندگان
, , , ,