Myogenic differentiation and lipid-raft composition of L6 skeletal muscle cells are modulated by PUFAs

► Membrane and DRM of L6 cells modify their lipid composition during differentiation ► PUFAs activate myogenic differentiation by altering lipid and protein compositions ► n-3 or n-6 PUFAs promote an increase of the phosphorylation of p70S6K ► We report that the myogenic differentiation is linked to membrane structural changes