کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1946872 1537290 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A switch in time: Detailing the life of a riboswitch
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A switch in time: Detailing the life of a riboswitch
چکیده انگلیسی

Riboswitches are non-protein coding RNA elements typically found in the 5′ untranslated region (5′-UTR) of mRNAs that utilize metabolite binding to control expression of their own transcript. The RNA–ligand interaction causes conformational changes in the RNA that direct the cotranscriptional folding of a downstream secondary structural switch that interfaces with the expression machinery. This review describes the structural themes common to the different RNA–metabolite complexes studied to date and conclusions that can be made regarding how these RNAs efficiently couple metabolite binding to gene regulation. Emphasis is placed on the temporal aspects of riboswitch regulation that are central to the function of these RNAs and the need to augment the wealth of data on metabolite receptor domains with further studies on the full regulatory element, particularly in the context of transcription.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1789, Issues 9–10, September–October 2009, Pages 584–591
نویسندگان
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