کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1946949 1054282 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromatin loops in gene regulation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Chromatin loops in gene regulation
چکیده انگلیسی

The control of gene expression involves regulatory elements that can be very far from the genes they control. Several recent technological advances have allowed the direct detection of chromatin loops that juxtapose distant genomic sites in the nucleus. Here we review recent studies from various model organisms that have provided new insights into the functions of chromatin loops and the mechanisms that form them. We discuss the widespread impact of chromatin loops on gene activation, repression, genomic imprinting and the function of enhancers and insulators.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1789, Issue 1, January 2009, Pages 17–25
نویسندگان
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