Biosurfactant mannosyl-erythritol lipid inhibits secretion of inflammatory mediators from RBL-2H3 cells

► Biosurfactants MELs inhibited exocytotic release from mast cells. ► MELs inhibited secretion of leukotriene C4 and TNF-α from mast cells. ► MELs inhibited Ca2+ increase, phosphorylation of MAP kinases and SNAREs. ► MELs had anti-allergic actions inhibiting secretion of inflammatory mediators.