کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950642 1055680 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolution of the unfolded protein response
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evolution of the unfolded protein response
چکیده انگلیسی

The unfolded protein response (UPR) is a network of signaling pathways that responds to stress in the endoplasmic reticulum (ER). The general output of the UPR is to upregulate genes involved in ER function, thus restoring and/or increasing the capacity of the ER to fold and process proteins. In parallel, many organisms have mechanisms for limiting the load on the ER by attenuating translation or degrading ER-targeted mRNAs. Despite broad conservation of these signaling pathways across eukaryotes, interesting variations demonstrate a variety of mechanisms for managing ER stress. How do early-diverging protozoa respond to stress when they lack traditional transcriptional regulation? What is the role of the ER stress sensor Ire1 in fungal species that are missing its main target? Here I describe how diverse species have optimized the UPR to fit their needs. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum.


► The UPR is an ancient network of pathways that responds to ER stress.
► Protozoa respond to ER stress through regulation of translation and mRNA stability.
► Plants rely largely on transcriptional responses to ER stress.
► The UPR in plants, as in animals, is important for secretory cell function.
► Studies in fungi suggest an alternative ancestral function for Ire1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1833, Issue 11, November 2013, Pages 2458–2463
نویسندگان
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