کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950718 1055692 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans
چکیده انگلیسی

The appearance of heme, an organic ring surrounding an iron atom, in evolution forever changed the efficiency with which organisms were able to generate energy, utilize gasses and catalyze numerous reactions. Because of this, heme has become a near ubiquitous compound among living organisms. In this review we have attempted to assess the current state of heme synthesis and trafficking with a goal of identifying crucial missing information, and propose hypotheses related to trafficking that may generate discussion and research. The possibilities of spatially organized supramolecular enzyme complexes and organelle structures that facilitate efficient heme synthesis and subsequent trafficking are discussed and evaluated. Recently identified players in heme transport and trafficking are reviewed and placed in an organismal context. Additionally, older, well established data are reexamined in light of more recent studies on cellular organization and data available from newer model organisms. This article is part of a Special Issue entitled: Cell Biology of Metals.


► Enzymology and regulation of heme biosynthesis.
► Supramolecular protein assemblies in heme synthesis.
► Heme transport and trafficking.
► Intracellular and intercellular heme transport.
► Heme-binding proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1823, Issue 9, September 2012, Pages 1617–1632
نویسندگان
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