Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM

► We found an increased intracellular Ca2+ in COPD patients as compared to healthy. ► Increased PKC levels and iNOS/eNOS imbalance also correlated with COPD severity. ► Altered parameters were found normalized by a novel Ca2+ channel blocker, H-DHPM. ► H-DHPM effectively increased eNOS levels by releasing it from caveolin bound form. ► The effects of H-DHPM were found comparative to amlodipine.