کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1953158 1057253 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flavonoids inhibit the amidolytic activity of human thrombin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Flavonoids inhibit the amidolytic activity of human thrombin
چکیده انگلیسی

The effect of a group of natural flavonoids on human thrombin amidolytic activity was investigated using a spectrophotometric inhibition assay while information on the kinetics and thermodynamics was obtained using optical biosensor techniques. All the flavonoids tested acted as reversible inhibitors, and the quercetin–thrombin complex was found to be most stable at pH = 7.5. Docking analysis indicated that quercetin's inhibitory behavior could be related to its planar structure and low steric hindrance, and to its ability to form a critical H-bond with thrombin His57.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 88, Issue 9, September 2006, Pages 1297–1306
نویسندگان
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