کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1964007 1058522 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis
چکیده انگلیسی

Cell adhesion molecules (CAMs) play a significant role in the metastatic potential of colorectal cancer and thus mediate the prognosis of this common malignancy. The downregulation of cadherins and catenins facilitates tumour cell detachment from the primary site, while the expression of selectins, integrins and members of the immunoglobulin superfamily may support neoplastic progression, intravasation and malignant cell attachment to foreign tissue, leading to the development of metastases. The liver is the main host organ of colorectal metastatic lesions. The process of hepatic invasion originates in the sinusoids, where non-parenchymal cells interact with metastasising ones, through the expression of numerous CAMs, following complex molecular pathways. Concurrently, the selective expression of cell adhesion molecules on different organs and endothelia, in conjunction with the presence of dissimilar adhesion ligands on various colorectal cancer cell lines, suggest that CAMs may also mediate the selection of the host organ, for the development of distant colorectal metastases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 21, Issue 5, May 2009, Pages 665–674
نویسندگان
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