Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1

► Ang II promotes cell survival through upregulation and activation of SGK1. ► Ang II increases the levels of SGK1 via calcium and tyrosine kinase signalling. ► Ang II increases the phosphorylation of SGK1 via an mTOR-dependent mechanism. ► SGK1 promotes cell survival by mediating the phosphorylation of FOXO3A at Thr32. ► These are novel mechanisms by which Ang II can mediate cell survival.