کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1964875 | 1058628 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling
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کلمات کلیدی
N-CAMCadherin-11N-cadherinFGFpKaPLCγFGFRERK1/2 - ERK1 / 2PI3 kinase - PI3 کینازNeurite outgrowth - رشد عصبیfibroblast growth factor - فاکتور رشد فیبروبلاستphospholipase Cγ - فسفولیپاز CγDAG lipase - لیپاز روزMigration - مهاجرتneural cell adhesion molecule - مولکول چسبندگی سلولی عصبیprotein kinase A - پروتئین کیناز AAdhesion - چسبندگیextracellular signal-regulated kinase 1 and 2 - کیناز 1 و 2 تنظیم شده با سیگنال خارج سلولیCaM kinase - کیناز CaMFGF Receptor - گیرنده FGF
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling](/preview/png/1964875.png)
چکیده انگلیسی
Cadherin-11 is a cell-cell adhesion molecule whose expression is often correlated with cellular migratory phenomena. We recently demonstrated that cadherin-11 activation by immobilized cad11-Fc (cadherin-11 ectodomain fused to Fc fragment) promotes axonal extension of spinal cord explants. Here, we show that this induced neurite outgrowth is dependent on the FGF receptor (FGFR) activity. Downstream, DAG lipase/CAM kinase and PI3 kinase pathways are required, but not the MAP kinase signalling. We also demonstrate that a tagged form of FGFR1 co-immunoprecipitates with β-catenin containing cadherin-11 immunocomplexes. FGFR1 and β-catenin show colocalization and enhanced association during cadherin-11 engagement, suggesting that FGFR1 interaction with cadherin-11 adhesion complexes is reinforced during cell contact formation. In vitro pull-down experiments using recombinant ectodomains suggest that cadherin-11/FGFR interact directly through their extracellular domains. Altogether, we propose that cadherin-11 recruits the FGFR upon adhesive engagement at nascent contacts, triggering the activation of downstream pathways involved in growth cone progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 20, Issue 6, June 2008, Pages 1061-1072
Journal: Cellular Signalling - Volume 20, Issue 6, June 2008, Pages 1061-1072
نویسندگان
Cécile Boscher, René-Marc Mège,