دانلود مقالات ISI درباره Plcγ + ترجمه فارسی

پاتولوژی پراکندگی در هسته های کولینرژیک بازالیس نورون ها با تغییرات ژن گیرنده نوروپاتیک و نوروترانسمیتر در طول پیشرفت بیماری آلزایمر

Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease

Keywords: Ache; acetylcholinesterase; AD; Alzheimer's disease; Adra2a, Adra2b, Adra1b; adrenoceptor alpha 2a, alpha 2b, beta 1; Akt1; Akt serine/threonine protein kinase 1/protein kinase B; ApoE; apolipoprotein E; Bche; butyrylcholinesterase; BDNF; brain derived ne

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

سیناپس ایمونولوژیک به عنوان هدف دارویی

The immunological synapse as a pharmacological target

Keywords: AP-1; activating protein 1; APC; antigen presenting cell; CAR; chimeric antigen receptors; Cbl-b; casitas B-lineage lymphoma; DAG; diacylglycerol; cSMAC; central supramolecular activation cluster; CTLA4; cytotoxic T lymphocyte antigen 4; dSMAC; distal sup

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

Structural characterization of recombinant human fibroblast growth factor receptor 2b kinase domain upon interaction with omega fatty acids

Keywords: hFGFR2b; human fibroblast growth factor receptor 2b; UFAs; unsaturated fatty acids; CD; circular dichroism; FGFRs; fibroblast growth factor receptors; RTK; receptor tyrosine kinase; Ig; immunoglobulin; PLCγ; phospholipase Cγ; FRS2; fibroblast growth fac

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

اقدامات قلب فاکتور رشد فیبروبلاست 23

Cardiac actions of fibroblast growth factor 23

Keywords: AngII; angiotensin II; CKD; chronic kidney disease; EGF; epidermal growth factor; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; FRS2α; FGF receptor substrate 2α; HPG; heparan sulfate proteoglycans; IGF-1; insulin-like growth fa

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

محصولات طبیعی برای درمان بیماری های فرسوده استخوانی: اثرات و مکانیزم هایی برای مهار استئوکلستوژنز و جذب استخوان

Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption

Keywords: MNCs; multinucleated cells; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor-κB ligand; M-CSF; macrophage colony stimulating factor; OPG; osteoprotegerin; c-fms; colony-stimulating factor-1 receptor; ERK; extracellul

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

پروتئین تیروزین فسفاتاز حاوی پروتئین حاوی هیستیدین باعث تنظیم و انقباض داخل سلولی گیرنده فاکتور رشد می شود

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

Keywords: HD-PTP; PDGFRβ; STAT3; c-Cbl; Cbl-b; PLCγ; ESCRT; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

تعامل بین گیرنده های تیروزین کیناز و سیگنالینگ هیپوکسی در سرطان

Interplay between receptor tyrosine kinases and hypoxia signaling in cancer

Keywords: ARNT; aryl hydrocarbon nuclear translocator; BCRP; breast cancer resistant protein; CAD; C-terminal activation domain; CAIX; carbonic anhydrase IX; CAV1; caveolin-1; ccRCC; clear cell renal cell carcinoma; CSC; cancer stem cells; DAG; diacylglycerol; DUSP

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

نقش مس در رگرسیون هیپرتروفی قلبی

Role of copper in regression of cardiac hypertrophy

Keywords: Copper; Cardiac hypertrophy; CCO; Angiogenesis; VEGFRs; HIF-1; ANG-1; angiopoietin-1; ANG-2; angiopoietin-2; ANP; atrial natriuretic peptide; ATOX1; antioxidant 1; ATP; adenosine triphosphate; BNP; B-type natriuretic peptide; BNIP3; BCL2/adenovirus E1B 19

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

سیگنالینگ گیرنده نوروتروپین محلی و دراز مدت: اندوسوم ها نه تنها حمل کننده برای حمل آکسون هستند

Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport

Keywords: Neurotrophins; Signalling endosome; Endosome acidification; Trk receptors; Membrane motility; Receptor internalization; AP-2; adaptor protein complex 2; BDNF; brain-derived neurotrophic factor; CREB; cAMP response element-binding protein; EEA1; early endo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

تأثیر پروفیل های گیرنده فاکتور رشد اندوتلیال عروقی بر ویژگی های آنژیوژنیک آنها

The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

Keywords: VEGF; vascular endothelial growth factor; VEGFR2; VEGF receptor 2; Nrp; Neuropilin; PlGF; placenta growth factor; PLCγ; phospholipase Cγ; VE-cadherin; vascular endothelial cadherin; TSAd; T-cell-specific adapter; HSPGs; heparan sulfate proteoglycans; Hs

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

بررسی ناهمگونی ناهموار و خلفی منطقه تکتونستیک شکمی

ReviewThe antero-posterior heterogeneity of the ventral tegmental area

Keywords: aVTA; anterior VTA; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; CREB; cAMP response element binding protein; EM-1; endomorphin-1; NMDA; N-methyl-d-aspartate; PLCγ; phospholipase Cγ; pVTA; posterior VTA; RMTg; rostromedial tegmental nucleus; tVTA; tail o

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

سلول های چند هسته ای ناشی از لیپوپلی پلی ساکارید: افزایش داخلی دانه های پلی استایرن و سیگنال های ممکن برای فیوژن سلولی

Lipopolysaccharide-induced multinuclear cells: Increased internalization of polystyrene beads and possible signals for cell fusion

Keywords: LPS; lipopolysaccharide; TLR4; toll-like receptor-4; RANKL; receptor activator of nuclear factor κB ligand; RANK; receptor activator of nuclear factor κB; FBGC; foreign body giant cell; MEMκ; minimum essential medium alpha medium; PBS; phosphate-buffer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

نوراپی نفرین فعالیت مهاجرت سلول های سرطانی پانکراس را مهار می کند

Norepinephrine inhibits the migratory activity of pancreatic cancer cells

Keywords: EGFR; Epidermal growth factor receptor; FITC; Fluorescein isothiocyanate; GPCR; G protein coupled receptor; IP3; Inositol-tris-phosphate; PIP2; Phosphatidyl-inositol-bis-phosphate; PLCγ; Phospholipase Cγ; PKA/C; Protein kinase A/C; PDGFR; Platelet-deriv

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle

Keywords: 7,8-DHF; 7,8-Dihydroxyflavone; ACC; accetyl CoA carboxylase; AdipoQ; adiponectin; AMPK; AMP-activated protein kinase; ANGPT-L3; angiopoietin-like 3; BAT; brown adipose tissue; BDNF; brain derived neurotrophic factor; CREB; cAMP responsive element binding

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation

Keywords: Breast Cancer; c-KIT; Epigenetics; DNA methylation; Immunohistochemistry; ADH; Atypical ductal hyperplasia; BCA; Bicinchoninic acid; CML; Chronic myelogenous leukemia; CK5/6; Cytokeratin 5/6; CK903; Cytokeratin 903; DCIS; Ductal Carcinoma in situ; ER; Est

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway

Keywords: ACC; acetyl-CoA carboxylase; Ac-Lys; acetylated lysine; AMPK; AMP-activated protein kinase; BMMCs; bone marrow-derived mast cells; HSA; human serum albumin; IKK; IκB kinase; IL-6; interleukin-6; JNK; c-Jun N-terminal kinase; LAT; linker for activation of

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2

Keywords: Endocytosis; Endothelial cells; Signaling; VEGF; VEGFR2; DAPI; 4′,6-diamidino-2-phenylindole dihydrochloride; ERK; extracellular signal-regulated kinase; HUVECs; human umbilical vein endothelial cells; MEK; mitogen-activated protein kinase/ERK kinase; m

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Distribution of BDNF and TrkB isoforms in growing antler tissues of red deer

Keywords: AACTB; actin-beta gene; B; bone; BDNF; brain-derived neurotrophic factor; BMPs; bone morphogenetic proteins; CA; non-mineralized cartilage; CP; chondroprogenitors; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; IGF-I; II insulin-lik

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Differences in Dural Penetration of Clival Chordomas Are Associated with Different Prognosis and Expression of Platelet-Derived Growth Factor Receptor-β

Keywords: Clival chordomas; Dura mater; Penetration; Platelet-derived growth factor receptor-β; Prognosis; mTOR; Mammalian target of rapamycin; NTR; Nontotal resection; OS; Overall survival; PDGFR-β; Platelet-derived growth factor receptor-β; PFS; Progression-fr

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease

Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5′AMP-activated protein kinase; BDNF; brain-derived neurotro

دانلود رایگان متن کامل مقاله ISI 91 صفحه سال انتشار : 2017 سفارش ترجمه

Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway

Keywords: PYGM; glycogen phosphorylase muscle isoform; Lck; lymphocyte-specific protein tyrosine kinase; PLCγ; phospholipase; PI3K; phosphatidylinositide 3-kinase; AKs; Janus kinases; STAT; signal transducer and activator of transcription; GEF; Guanine Nucleotide

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Cell confluence induces switching from proliferation to migratory signaling by site-selective phosphorylation of PDGF receptors on lipid raft platforms

Keywords: DAG; diacylglycerol; GM1; monosialotetrahexosylganglioside; GRB2; growth factor receptor binding protein-2; IP3; inositol 1,4,5-trisphosphate; PDGF; platelet-derived growth factor; PDGF-BB; homodimer of the B isoform of platelet derived growth factor); PD

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3′,5′-cyclic adenosine monophosphate;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development

Keywords: AR; acrosome reaction; Ca2+; calcium; [Ca2+]i; intracellular calcium; DAG; sn 1,2-diacylglycerol; DRM; detergent resistant membranes or rafts; EGF; epidermal growth factor; ER; endoplasmic reticulum; FIPI; 5-fluoro-2-indolyl des-chlorohalopemide; IP3; ino

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of hippocampal synaptic plasticity by BDNF

Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

Astrogliosis as a therapeutic target for neurodegenerative diseases

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V

Keywords: PDGFRA; PTPN11; SHP2; STAT5; Chronic eosinophilic leukemia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FLT3; Fms-like tyrosine kinase 3; FPα; FIP1L1-PDGFRα; GIST; gastrointestinal stromal tumors; MAPK; mitogen-activated protein

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

NFAT as cancer target: Mission possible?

Keywords: ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

Keywords: FFAR1; free fatty acid receptor 1; FFAs; free fatty acids; PIO; pioglitazone; PA; palmitic acid; ROS; reactive oxygen specific; PLCγ; Phospholipase C γ; ERK1/2; extracellular signal-regulated kinase 1/2; PPARγ; peroxisome proliferator activated recepto

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Cell recognition molecule L1 promotes embryonic stem cell differentiation through the regulation of cell surface glycosylation

Keywords: L1; Cell differentiation; ESC (embryonic stem cell); Glycosylation; PLCγ;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands

Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity

Keywords: 5-FU; 5-fluorouracil; BrdU; 5-bromo-2′-deoxyuridine; FACS; fluorescence activated cell sorting; FAK; focal adhesion kinase; GMP; granulocyte-monocyte progenitor; HPC; hematopoietic progenitor cell; KLS; c-Kit+lineage−Sca-1+; LT-HSC; long-term hemato

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation

Keywords: IFE; Inulae Flos extract; BMMCs; bone marrow-derived mast cells; IL-3; interleukin-3; LTC4; leukotriene C4; SCF; stem cell factor; cPLA2; cytosolic phospholipase A2; MAPKs; mitogen-activated protein kinases; PLCγ; phospholipase Cγ; AA; arachidonic acid;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer

Keywords: RhoGDI2; PLCγ; Cisplatin; Apoptosis; Invasion;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Anti-proliferative actions of 2-decylamino-5,8-dimethoxy-1,4-naphthoquinone in vascular smooth muscle cells

Keywords: 2-decylamino-DMNQ; 2-decylamino-5,8-dimethoxy-1,4-naphthoquinone; VSMCs; vascular smooth muscle cells; PDGF; platelet-derived growth factor; Erk1/2; extracellular regulated kinases 1/2; PLCγ; phospholipase γ; PDGF-Rβ; PDGF receptor β; CDK; cyclin-depe

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Slow intracellular accumulation of GABAA receptor δ subunit is modulated by brain-derived neurotrophic factor

Keywords: ligand-gated ion channels; internalization; hippocampus; PLCγ; PKC; biotinylation assay; ANOVA; analysis of variance; AP2; adapter protein 2; BDNF; brain-derived neurotrophic factor; GABARs; GABAA receptors; PBS; phosphate buffered saline; PDBu; phorbol

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling

Keywords: Cad11-Fc or Ncad-Fc; cadherin-11 or N-cadherin extracellular domain fused to the human-Fc fragment of immunoglobulin; N-CAM; Neural Cell Adhesion Molecule; CAM kinase; Calmoduline kinase; DAG lipase; Diacyl glycerol lipase; ERK1/2; extracellular signa

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The nerve growth factor and its receptors in airway inflammatory diseases

Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of Src/kinase/phospholipase c/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor

Keywords: ATP; P2Y receptor; MAP kinase; neurite outgrowth; neuro2a cells; BSA; bovine serum albumin; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; MEK; MAP kinase/ERK kinase kinase; MAPK; mitogen-activated protein kinase; NECA; 5′

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Modulation of signal transduction by tea catechins and related phytochemicals

Keywords: EGFR; epidermal growth factor receptor; RTK; receptor tyrosine kinase; EGCG; (−)-epigallocatechin-3-gallate; EGC; (−)-epigallocatechin; ECG; (−)-epicatechin-gallate; EC; (−)-epicatechin; TGFα; transforming growth factor α; EGF; epidermal growth

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Right time, right place: the organization of membrane proximal signaling

Keywords: AP-1; activator protein 1; Bam32; B-lymphocyte adaptor molecule of 32 kDa; BCR; B-cell receptor; Cbp; Csk binding protein; Csk; carboxyl-terminal Src kinase; DAG; diacylglycerol; DAPP1; dual adaptor for phosphotyrosine and 3-phosphoinositides; ERK; extra

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه