PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer

► RhoGDI2 plays an important role for malignant progression in gastric cancer. ► RhoGDI2 contributes to resistance to chemotherapeutic agents such as cisplatin. ► PLCγ is activated by RhoGDI2 expression in gastric cancer. ► PLCγ plays a key role in RhoGDI2-mediated cisplatin resistance in gastric cancer cells. ► PLCγ is required for RhoGDI2-overexpressing gastric cancer cell invasion.