کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965281 1538655 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure
چکیده انگلیسی


• miRNA expression profiling can be a diagnostic and predictive tool for Heart Failure.
• Circulating miRNAs constitute potential biomarkers in Heart Failure.
• miRNAs might have potential applications in targeted therapeutics for Heart Failure.
• Next Generation Sequencing enables the discovery of novel miRNAs.
• Next Generation Sequencing identified miRNAs not previously related to Heart Failure.

miRNAs are small non-coding RNAs that regulate gene expression. They have significant role in the regulation of cardiovascular function and conditions, such as Heart Failure (HF), as demonstrated by studies of miRNA expression profiling in myocardial tissue. The importance of the use of miRNAs as biomarkers in HF was enhanced when found that they exist extracellularly, with remarkable stability and there are indications that their expression levels reflect the cell response in cardiovascular conditions including Heart Failure. Advances in technology and bioinformatics broaden the field of applications of miRNAs in HF. The introduction of new platforms, such as Next Generation Sequencing, enabled the discovery of novel miRNAs that might be utilized as Heart Failure biomarkers for diagnostic and prognostic purposes and with potential applications in targeted therapeutics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 443, 30 March 2015, Pages 114–119
نویسندگان
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