کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1966413 | 1538705 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: MAP kinases in inflammatory bowel disease MAP kinases in inflammatory bowel disease](/preview/png/1966413.png)
The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD).This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD.
Journal: Clinica Chimica Acta - Volume 412, Issues 7–8, 18 March 2011, Pages 513–520