کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966849 1538730 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of miR-106a in gastric carcinoma and its clinical significance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Detection of miR-106a in gastric carcinoma and its clinical significance
چکیده انگلیسی

BackgroundMicroRNAs (miRNAs) play important roles in carcinogenesis. miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood.MethodsThe level of miR-106a in 55 gastric carcinoma and 17 non-tumor tissues was quantified by real-time reverse transcriptase-polymerase chain reaction, and the relationship between miR-106a level and clinical and pathological factors was explored.ResultsThe level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P < 0.01). The altered expression of miR-106a was confirmed in gastric cancer cell lines.ConclusionmiR-106a may be a potential biomarker in the diagnosis of gastric carcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 400, Issues 1–2, February 2009, Pages 97–102
نویسندگان
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