کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966973 1538737 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women
چکیده انگلیسی

BackgroundThe present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women.MethodsThe participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants.ResultsHealthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease.ConclusionsThere was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 392, Issues 1–2, June 2008, Pages 11–16
نویسندگان
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